Today we lean that Microsoft has lost it's appeal regarding their monopolistic practices in Europe. I foretell that Microsoft will continue with business as usual and otherwise completely disregard the ruling and the penalties. So, they may pay the fiscal part of the penalties but the rest of it will have to wait for Satan to get a new job as a snow-plough driver in hell.
What can be done about it? Quite simple. It is within the EU's power to void Microsoft's copyrights, patents, trademarks and all other intellectual property in Europe.
Radical, yes. But it would also serve as a warning for all other companies that they are not above the law. Europe is a big market for Microsoft ... bigger than their American market.
I doubt that would ever happen but it doesn't hurt to dream.